The Effect of Elemental Diet on Intestinal Permeability and Inflammation in Crohn’s Disease

Studies have confirmed that an elemental diet is an effective treatment for active Crohn’s disease without serious side effects. However, the mechanism of action of an elemental diet in Crohn’s disease is poorly
understood. Also it is unclear whether an elemental diet has a primary effect on disease activity in addition to providing symptomatic relief. As a result, a study was undertaken to examine the effect of treatment with an elemental diet on intestinal permeability and inflammation in active Crohn’s disease.

Treatment of Active Crohn’s Disease by Exclusion Diet: East Anglian Multicentre Controlled Trial

The management of Crohn’s disease (CD) is unsatisfactory. Many of the drugs used are not always effective or have serious side effects. Elemental diets can be as effective as steroids in inducing remission in acute CD, however patients often relapse when they recommence a normal diet. In this study, the use of an elemental diet in acute CD and the efficacy of dietary modification or oral corticosteroids in maintaining remission achieved by an elemental diet were examined.

Oral Nutritional Supplementation is Effective in the Maintenance of Remission in Crohn’s Disease

Enteral nutrition using an elemental formula is a recognised primary treatment for active Crohn’s Disease (CD). Whether supplementation of a normal diet with an elemental formula has a role in the long-term management of CD is unknown and was examined in this study.

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